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KU Center for Technology Commercialization

    Innovation Sphere


  • Steven Hoynowski
  • Kathy Mitchell



Project TitleDifferentiation of HUCM Cells into Hepatocyte Lineage Cells
Track Code06KU050L
Short Description

This is a method for differentiating umbilical cord matrix stem cells into cells of the hepatocyte lineage that express albumin, alpha fetoprotein, cytochrome p450 isoforms and store glycogen.

Tagsstem cells, HUCM Cells, Hepatocyte Lineage Cells
Posted DateSep 3, 2013 12:22 PM


Steven Hoynowski
Kathy Mitchell


Matthew Koenig


The differentiated human umbilical cord matrix (HUCM) cells have the ability to metabolize the drug indocyanine green, as liver cells do. The differentiated HUCM cells also resemble hepatocytes morphologically.


This source of cells provides the potential for genetic diversity by creating a bank of differentiated cells from diverse populations which would better represent the population at large. This is currently a weakness in drug screening studies early in the drug discovery process. Differentiated cells could also be applied to damaged liver tissue. Replacement of such tissue would provide an alternative to whole organ transplant by as a cell-based therapy or by growing the HUCM cells and differentiating them on a three dimensional scaffold to used as an artificial partial organ to restore loss of function in damaged liver.


The ability to direct HUCM stem cells to differentiate into hepatocytes extends the utility of this abundant source of stem cells for use in areas of drug research. For example, these cells could be used to test drug candidate molecules for their potential ability to produce hepatotoxicity, induction of cytochrome P450 gene expression, and inhibition of drug metabolic pathways. Realizing the goal of differentiating HUCM cells down the hepatocyte lineage would thereby provide a more readily available supply of human cells to be used in the assessment of possible drug-drug interactions.

Contact Information

Matt Koenig, J.D.

KU Center for Technology Commercialization (785) 864-1774

Intellectual Property

Patent Number Issue Date Type Country of Filing
US2008/0019949 None Utility United States

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